By understanding its natural history, eliminating or reducing predisposing factors such as smoking and obesity, appreciating the complexities of the immunologic aberrations leading to mucin deposition, and having a logical approach to therapy, clinicians should be able to at least ameliorate this chronic, occasionally severe, recalcitrant disorder.
Pretibial myxedema like lesions may occur in chronic stasis dermatitis, but histopathology of such lesions show mucin deposition in papillary dermis along with hemosiderin deposition and nodular angiogenesis.
Pretibial myxedema (myxoedema (UK), also known as Graves' dermopathy, thyroid dermopathy, Jadassohn-Dösseker disease or Myxoedema tuberosum) is an infiltrative dermopathy, resulting as a rare complication of Graves' disease, with an incidence rate of about 1-5%. Contents 1 Signs and symptoms 2 Risk factors 3 Diagnosis 4 Management 5 References
Pretibial myxedema is also called thyroid dermopathy, localized myxedema and infiltrative dermopathy, is a form of diffuse mucinosis in which there is an accumulation of excess glycosaminoglycans in the dermis and subcutis of the skin, usually as a component of thyroid disease.
It is also referred to as thyroid dermopathy, Myxoedema tuberosum, Jadassohn-Dosseker disease, or localized myxedema. Pretibial myxedema is used to describe lesions of your skin that are localized. When they are referring to the pretibial area of your body the physician is talking about your shin and the front part of your lower legs. Symptoms
Symptoms. When a person has pretibial myxedema it is characterized by: A localized thickening of the skin primary on the lower legs and shins. It can affect your shoulders, upper legs, back, arms, neck, face, torso, and ears. With the skin thickening it can be accompanied by dryness, edema that is non-pitting which means when you put pressure.
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