A half dose of Pfizer as a booster instead of a full dose proved to be only slightly less effective with a 1,002 GMT against Delta and a 507 GMT against Omicron. The study showed that a Pfizer booster after 2 AstraZeneca vaccines is a fair amount less effective than starting with 2 Sinovac injections.
While the Pfizer vaccine will continue to offer protection to 20% to 24% of fully-vaccinated individuals, the Sinovac vaccine offers no protection at all. The Geometric Mean Titre (GMT) results in this study also suggest that a third (booster) dose will boost the Pfizer vaccine’s neutralising antibody response against the Omicron variant.
Whereas the Pfizer-BioNTech, Moderna and AstraZeneca vaccines all require two doses about 28 days apart, the J&J vaccine requires only a single dose. The Phase III ENSEMBLE trial demonstrated the single-shot vaccine is 66% effective overall in preventing moderate-to-severe COVID-19, 28 days after vaccination.
A 95% effective vaccine is better than a 62% to 90% effective vaccine, but 200 million doses is better than 20 million to 50 million doses. In short, Pfizer and Moderna are producing fewer but more effective (and pricier) vaccines, while AstraZeneca is making a greater number of less effective (and cheaper) vaccines. Tags: vaccines coronavirus
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