Genomic hotspots enriched with mutations, particularly those resulting in functional modifications, were also identified. Loss-of-function (LOF) variants present in the Malay samples were also compared to those reported in the 1KGP pilot.
We built a Malay-specific reference panel to impute ethnic-specific variants and validate the associations with HbA1c at ethnic-specific variants. Results: Meta-analysis of the 1000 Genomes imputed array data identified 4 loci at genome-wide significance (P < 5 × 10-8). Of the 4 loci, 3 (ADAM15, LINC02226, JUP) were novel for HbA1c associations.
Our platform can fulfill all your requirements for genome modification in today’s experimental organisms, including mouse, rat and other species. Working together with the Phenomics Australia node at Monash and the Monash Animal Research Platform, we deliver a comprehensive service in whole animal genome modification using CRISPR, embryonic.
The Singapore Sequencing Malay Project (SSMP) aims to perform deep, population-level whole-genome sequencing of 100 healthy Singapore Malays. Malays are an ethnic group of Austronesian-speaking people predominantly inhabiting the modern countries of Singapore, Malaysia, and Indonesia in the Southeast Asian region.
Genome editing allows scientists to make changes to a specific “target” site in the genome. One of the techniques that have generated the most excitement, due to its efficiency and ease of use, is called “CRISPR.”. CRISPR stands for “clustered regularly interspaced short palindromic repeats.”. The basis of CRISPR technology is a.
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