Heterologous vaccine - Homologous and Heterologous Covid
AU - Nayak, S.
EMA and ECDC recommendations on heterologous vaccination courses against COVID
METHODS In this phase 1β2, open-label clinical trial conducted at 10 sites in the United States, adults who had completed a Covid-19 vaccine regimen at least 12 weeks earlier and had no reported history of severe acute respiratory syndrome coronavirus 2 SARS-CoV-2 infection received a booster injection with one of three vaccines: mRNA-1273 Moderna at a dose of 100 ΞΌg, Ad26.
Description: Homologous boosters increased neutralizing antibody titers by a factor of 4 to 20, whereas heterologous boosters increased titers by a factor of 6 to 73.
Conclusion: Homologous and heterologous booster vaccinations were well-tolerated and immunogenic in adults who completed a primary Covid-19 vaccine regimen at least 12 weeks earlier. (Funded by National Institute of Allergy and Infectious Diseases; Clinical Trials.gov number, NCT04889209 ). Publication types Preprint Associated data
16 December 2021. Departmental news. Reading time: Less than a minute (23 words) The interim recommendations for heterologous COVID-19 vaccine schedules is now published. For further information, see below:
Taken together, the investigators concluded, these data strongly suggest that homologous and heterologous booster vaccine will increase protective efficacy against symptomatic SARS-CoV-2 infection
Homologous and Heterologous Covid-19 Booster Vaccinations Robert L. Atmar, M.D., Kirsten E. Lyke, M.D., Meagan E. Deming, M.D., Ph.D., Lisa A. Jackson, M.D., M.P.H., Angela R. Branche, M.D., Hana .
Heterologous immunity is a term used to describe the partial immunity (or altered immunopathology) that occurs in response to a pathogen if the host has been previously infected or immunized with an unrelated pathogen. In some cases, heterologous immunity is attributed to T cells that crossreact with both pathogens.
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